For the Michaelis-Menten model we determine designs which maximize the minimum of the D-efficiencies over a certain interval for the non-linear parameter. The best two point designs can be found explicitly and a characterization is given, when these designs are optimal within the class of all...

For the binary response model, we determine optimal designs which are robust wit respect to the misspecifications of the unknown parameters. We propose a maximin approach and provide a numerical method to identify the best two point designs for the commonly applied link functions. This method is...

For the compartmental model we determine optimal designs, which are robust against misspecifications of the unknown model parameters. We propose a maximin approach based on D-efficiencies and provide designs that are optimal with respect to the particular choice of various parameter regions.