Technological advances make it possible to use high-throughput sequencing as a primary discovery tool of medical genetics, specifically for assaying rare variation. Still this approach faces the analytic challenge that the influence of very rare variants can only be evaluated effectively as a...

Reviewer: Murray, Peter

We present two recent integer programming models in molecular biology and study practical reformulations to compute solutions to some of these problems. In extension of previously tested linearization techniques, we formulate corresponding semidefinite relaxations and discuss practical rounding...

The purpose of this paper is to review some recent applications of coalitional games in medical research, and to illustrate some related open questions. We point out the fact that many problems which are still object of debate deal with the computation, the statistical comparison and the...