Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit. We compared the efficiency and accuracy of the Response Surface Methodology and the Nelder and Mead Simplex Method for...

We develop a framework for automated optimization of stochastic simulation models using Response Surface Methodology. The framework is especially intended for simulation models where the calculation of the corresponding stochastic response function is very expensive or time-consuming. Response...

In the warehouse of Ankor, a wholesaler of tools and garden equipment, various problems concerning the storage and retrieval of products arise. For example, heavy products have to be retrieved prior to light products to prevent damage. Furthermore, the layout of the warehouse differs from the...

A railway system needs a substantial amount of maintenance. To prevent unexpected breakdowns as much as possible, preventive maintenance is required. In this paper we discuss the Preventive Maintenance Scheduling Problem (PMSP), where (short) routine activities and (long) unique projects have to...

In the warehouse of Ankor, a wholesaler of tools and garden equipment, various problems concerning the storage and retrieval of products arise. For example, heavy products have to be retrieved prior to light products to prevent damage. Furthermore, the layout of the warehouse differs from the...

We develop a framework for automated optimization of stochastic simulation models using Response Surface Methodology. The framework is especially intended for simulation models where the calculation of the corresponding stochastic response function is very expensive or time-consuming. Response...

A railway system needs a substantial amount of maintenance. To prevent unexpected breakdowns as much as possible, preventive maintenance is required. In this paper we discuss the Preventive Maintenance Scheduling Problem (PMSP), where (short) routine activities and (long) unique projects have to...

Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit. We compared the efficiency and accuracy of the Response Surface Methodology and the Nelder and Mead Simplex Method for...