For a broad class of nonlinear regression models we investigate the locally E- and c-optimal design problem. It is demonstrated that in many cases the optimal designs with respect to these optimality criteria are supported at the Chebyshev points, which are the local extrema of the...

In the Michaelis-Menten model we determine efficient designs by maximizing a minimum of standardized E-efficiencies. It is shown that in many cases the optimal designs are supported at only two points and the support points and corresponding weights can be characterized explicitly. Moreover, a...

In this paper the optimal design problem for the estimation of the individual coefficients in a polynomial regression on an arbitrary interval [a, b] (- inf. a b inf) is considered. Recently, Sahm (2000) demonstrated that the optimal design is one of four types depending on the symmetry...

In this paper we investigate locally E- and c-optimal designs for exponential regression models of the form _k i=1 ai exp(??ix). We establish a numerical method for the construction of efficient and locally optimal designs, which is based on two results. First we consider the limit ?i ? ? and...

In this paper D-optimal designs for free knot least squares spline estimation are investigated. In contrast to most of the literature on optimal design for spline regression models it is assumed that the knots of the spline are also estimated from the data, which yields to optimal design...