In recent years, UK governments have implemented policies that emphasise the ability of parents to choose which school they wish their child to attend. Inherently spatial school-place allocation rules in many areas have produced a geography of inequality between parents that succeed and fail to...

The use of agent-based modelling approaches in ex-post and ex-ante evaluations of agricultural policies has been progressively increasing over the last few years. There are now a sufficient number of models that it is worth taking stock of the way these models have been developed. Here, we...

As a conceptual framework for understanding contemporary sustainability challenges, telecoupling emphasises the importance of socioeconomic and environmental interactions over long distances. These long-distance interactions can occur through multiple human activities. Here we focus on...

The mitochondrial pyruvate carrier (MPC) is a novel target for therapeutic drugs to treat Alzheimer's and Parkinson's disease, diabetes mellitus, and non-alcoholic steatohepatitis (NASH). Metabolic Solutions Development Company (MSDC) has two thiazolidinediones, MSDC-0160 and MSDC-0602, in the...

Thiazolidinedione (TZD) drugs (Takeda Pharmaceuticals and Metabolic Solutions Development Company) targeting inhibition of the mitochondrial pyruvate carrier (MPC) are currently being tested in clinical trials to prevent progression into mild cognitive impairment of Alzheimer's disease (AD) or...