The relative index of inequality (RII) is a commonly used measure of the extent to which the occurrence of an outcome such as chronic illness or early death varies with socioeconomic status or some other background variable. The standard RII estimator applies only to linear variation in...

In two-group discriminant analysis, the Neyman-Pearson Lemma establishes that the ROC, receiver operating characteristic, curve for an arbitrary linear function is everywhere below the ROC curve for the true likelihood ratio. The weighted area between these two curves can be used as a risk...

This work is motivated by dose-finding studies, where the number of events per subject within a specified study period form the primary outcome. The aim of the considered studies is to identify the target dose for which the new drug can be shown to be as effective as a competitor medication....

This paper is concerned with a paradox associated with parameter estimation in the presence of nuisance parameters. In a statistical model with unknown nuisance parameters, the efficiency of an estimator of a parameter usually increases when the nuisance parameters are known. However the...

Die Regierung der Deutschen Demokratischen Republik (DDR) sowie die Regierungen von Bund und Ländern der Bundesrepublik Deutschland haben im Juli 1990 den Wissenschaftsrat gebeten, gutachtlich zu den außeruniversitären Forschungseinrichtungen in der damaligen DDR Stellung zu nehmen. Es...

Part 1. Markets & Strategies -- Chapter 1. Development of the Life Sciences Industry Over the Past 30 Years -- Chapter 2. Venture Capital Perspectives on Life Science Innovation -- Chapter 3. Implications of Precision Medicine on Marketing & Sales Strategies -- Chapter 4. Intellectual Property...

"This book specifically provides the reader with the methodologies necessary to create a successful life sciences start-up from initiation to exit. The readers gain an appreciation for the necessary data, partnership, and skills to be acquired and the constituencies that must be satisfied, along...