Postmenopausal osteoporosis is characterized by an increased rate of bone turnover accompanied by a reduction in bone mineral density (BMD) that results in an increased risk of fracture, especially of the vertebrae, hip, or wrist. Alendronate (Fosamax(R), Fosamax Once-Weekly(R)), an oral...

Obesity has a significant impact on both morbidity and mortality, as well as an individual's capacity to live a full and active life. Traditionally, outcome measures in obesity treatments have emphasised physiological variables such as amount of bodyweight lost and improvements in various health...

Although Medicare risk plans have been withdrawn in a number of US geographical areas, the size and dollar value associated with the senior demographic group is too large for health plans to ignore. Unlike other developed nations, the US government offers to Medicare-eligible citizens a choice...

Clinical trials and meta-analyses of trials are models of clinical reality. A pharmacoeconomic model is a logical, quantitative blend of therapeutic and/or disease management strategies, evidence-based clinical outcomes, patient survival data and/or quality-of-life (utility) data,...

Paclitaxel belongs to the group of antitumor agents called the taxanes. Its efficacy in advanced ovarian cancer has been established in large, randomized phase III clinical trials. When used in combination with cisplatin for first-line treatment of advanced ovarian cancer, it is superior to...

Although clinicians have an obligation to act in patients' best interests, patients frequently choose to act in ways that adversely affect health. Consequently, clinicians are often left questioning where the responsibility for optimum care lies. The criteria for determining responsibility (the...

Asthma disease management (DM) programmes often focus on patients who are considered to be high resource users, such as those with recent emergency department visits and/or hospitalisations, or patients who have been diagnosed with severe persistent asthma. These programmes often focus on a few...

Cystic fibrosis (CF) is a serious genetically inherited multisystem disease, characterised by symptoms of pancreatic insufficiency, meconium ileus, obstruction/absence of the vas deferens and chronic obstruction, infection and inflammation of the lower respiratory tract. Lung disease,...

Parkinson's disease, a movement disorder caused by degeneration of nigrostriatal dopaminergic neurons in the substantia nigra, is characterized by resting tremor, rigidity, bradykinesia and postural instability. For over 30 years levodopa has been considered as the first-line treatment for this...