In the Michaelis-Menten model we determine efficient designs by maximizing a minimum of standardized E-efficiencies. It is shown that in many cases the optimal designs are supported at only two points and the support points and corresponding weights can be characterized explicitly. Moreover, a...

In this paper the optimal design problem for the estimation of the individual coefficients in a polynomial regression on an arbitrary interval [a, b] (- inf. a b inf) is considered. Recently, Sahm (2000) demonstrated that the optimal design is one of four types depending on the symmetry...

In the common trigonometric regression model we investigate the optimal design problem for the estimation of the individual coefficients, where the explanatory variable varies in the interval [-a ,a] ; 0 a t. It is demonstrated that the structure of the optimal design depends sensitively on...

In this paper we investigate locally E- and c-optimal designs for exponential regression models of the form _k i=1 ai exp(??ix). We establish a numerical method for the construction of efficient and locally optimal designs, which is based on two results. First we consider the limit ?i ? ? and...

In the common Fourier regression model we investigate the optimal design problem for estimating pairs of the coefficients, where the explanatory variable varies in the interval [¡ơ; ơ]. L-optimal designs are considered and for many important cases L-optimal designs can be found explicitly,...

If a model is fitted to empirical data, bias can arise from terms which are not incorporated in the model assumptions. As a consequence the commonly used optimality criteria based on the generalized variance of the estimate of the model parameters may not lead to efficient designs for the...