Karrison, Theodore G.; Ratain, Mark J.; Stadler, Walter M. - In: The American Statistician 66 (2012) 3, pp. 155-162
The randomized discontinuation trial (RDT) design is an enrichment-type design that has been used in a variety of diseases to evaluate the efficacy of new treatments. The RDT design seeks to select a more homogeneous group of patients, consisting of those who are more likely to show a treatment...