Gauzère Franck, Commenges Daniel, Barberger-Gateau Pascale, Letenneur Luc, Dartigues Jean-François.- Illness and dependency: description of changes using multistate models The progression of an illness can be modelled with a three-state model: healthy, ill, dead. The model used in this article...

HIV dynamical models are often based on non-linear systems of ordinary differential equations (ODE), which do not have an analytical solution. Introducing random effects in such models leads to very challenging non-linear mixed-effects models. To avoid the numerical computation of multiple...