Abstract We address several questions relating to the use of standard regression and Structural Nested Mean Model (SNMM) approach (e. g., Ten Have et al. 2007) to analyze post-randomization effect modifiers of the intent-to-treat effect of a randomized intervention on a subsequent outcome,...

We propose a multivariate growth curve mixture model that groups subjects on the basis of multiple symptoms measured repeatedly over time. Our model synthesizes features of two models. First, we follow Roy and Lin in relating the multiple symptoms at each time point to a single latent variable....

An employee stock ownership plan (quot;ESOPquot;) is a defined contribution retirement plan designed to invest primarily in stock of the sponsoring employer (or an affiliated employer) that finances the purchase of such stock through a loan from, or guaranteed by, the sponsoring employer. In...