We develop a novel approach for testing treatment effects in high-throughput data. Most previous works on this topic focused on testing for differences between the means, but recently it has been recognized that testing for differential variation is probably as important. We take it a step...

Gibbs sampling has had great success in the analysis of mixture models. In particular, the “latent variable” formulation of the mixture model greatly reduces computational complexity. However, one failing of this approach is the possible existence of almost-absorbing states, called trapping...