In vitro neuronal networks are a simplified and accessible model of the central nervous system. Moreover, they exhibit morphological and physiological properties and activity-dependent path-specific synaptic modification similar to the in vivo tissue. Cortical neurons grown on multi electrode...

The main objective of this report is to give an overview of the analytical strategies and modern laboratory techniques needed to perform a fast unambiguous identification and characterisation of unknown organic chemical substances such as New Psychoactive Substances (NPS). The "routine"...

There is a need to integrate existing in vitro dose-response data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would contribute towards the reduction of animal use in toxicology by using in vitro data for...

In this report, an integrated model including fate of contaminants and ecological models it is presented. The model has been developed for analysing the effects of contaminants at ecosystem level. The fate model was already presented in a previous report where it was implemented for the major...

A fundamental problem in ecotoxicology is the prediction of long term population and ecosystem-level effects of contaminant exposure based on dose response data of few individuals obtained over a short time period. In addition, environmental fluctuations will always affect significantly the...

We present an empirical analysis of the European electronic interbank market of overnight lending (e-MID) during the years 1999–2009. The main goal of the paper is to explain the observed changes of the cross-sectional dispersion of lending/borrowing conditions before, during and after the...