The inclusion of economic evaluations as part of clinical trials has led to concerns about the adequacy of trial sample size to support such analysis. The analytical tool of cost-effectiveness analysis is the incremental cost-effectiveness ratio (ICER), which is compared with a threshold value...

Since 1962 the world trades in bulk commodities as a whole have undergone two great changes: a large increase in the volume, and a large increase in the distance of the average route. In these years, trade in the five main dry bulk commodities doubled in tonnage, and in crude oil trebled in...