Multiple sclerosis (MS) is a demyelinating disease of the central nervous system whose cause is still unknown. The disease course shows great inter- and intra-individual variability and this results in insecurity of diagnosis and prognosis. A well-founded knowledge of the natural history of MS,...

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system whose cause is still unknown. The disease course shows great inter- and intra-individual variability and this results in insecurity of diagnosis and prognosis. A well-founded knowledge of the natural history of MS,...

We propose geoadditive survival models for analyzing effects jointly with possibly nonlinear effects of other covariates. Within a unified Bayesian frame work, our approach extends the classical Cox model to a more general multiplicative hazard rate model, augmenting the common linear predictor...

Structured additive regression comprises many semiparametric regression models such as generalized additive (mixed) models, geoadditive models, and hazard regression models within a unified framework. In a Bayesian formulation, nonparametric functions, spatial effects and further model...

This technical report supplements the paper Geoadditive Survival Models (Hennerfeind, Brezger and Fahrmeir, 2005, Revised for JASA). In particular, we describe the simulation study of this paper in greater detail, present additional results for the application, and provide a complete proof of...