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Emergence of Resistance in Influenza With Compensatory Mutations

MOGHADAS, SEYED - In: Mathematical Population Studies 18 (2011) 2, pp. 106-121

Compensatory mutations are evolutionary responses of influenza viruses resulting in the generation of escape mutants from immune recognition or in the emergence of highly transmissible drug resistant viruses. Model simulations show that: (i) resistance is unlikely to develop without compensation...

Persistent link: https://www.econbiz.de/10009205610

Modeling viral coevolution: HIV multi-clonal persistence and competition dynamics

Bagnoli, F.; Liò, P.; Sguanci, L. - In: Physica A: Statistical Mechanics and its Applications 366 (2006) C, pp. 333-346

number of viruses, most notably HIV, Marburg and Ebola, but the conditions for the formation and survival of new strains have … not yet been understood. We present a model of HIV quasispecies competition, which describes the conditions of viral … distribution of HIV quasispecies during disease progression, vaccination and therapy. …

Persistent link: https://www.econbiz.de/10011058645

Laboratory Professionals in Africa: The Backbone of Quality Diagnostics

Schneidman, Miriam; Dacombe, Russell J.; Carter, Jane - Economics Research, World Bank Group - 2014

Laboratories have historically been under supported in developing country health systems resulting in poor quality diagnosis and inadequate disease surveillance. Laboratory professionals are predominantly male with relatively limited female labor participation, with potential gender based...

Persistent link: https://www.econbiz.de/10011100430

Cost-effectiveness of an atypical conventional antipsychotic in South Africa: An economic evaluation of quetiapine versus haloperidol in the treatment of patients partially respons...

Emsley R.; Booysen F. - 2004

Background. The introduction of a new generation of atypical antipsychotic agents has raised difficult economic and ethical questions, particularly in lower-income countries. The reported tolerability and efficacy advantages of the atypical antipsychotics over their conventional predecessors...

Persistent link: https://www.econbiz.de/10009480496

Dynamics of Hepatitis B Virus Infection: What Causes Viral Clearance?

CIUPE, STANCA; CATLLA, ANNE; FORDE, JONATHAN; … - In: Mathematical Population Studies 18 (2011) 2, pp. 87-105

The virus Hepatitis B infects liver cells, leading to either acute or chronic liver disease. Immune responses involve both curing and killing of cells. Stability analyses show that viral clearance depends only on the strength of the combined killing and curing, independent of the characteristics...

Persistent link: https://www.econbiz.de/10009205547