The inability to measure individual risk for SUD, particularly at a young age, hinders etiologic research and prevention. Previous research has developed an index of transmissible liability (TLI)that covers the entire range of liability phenotypes, does not rely on SUD symptoms, is derived from...

People with familial history of disease often consult with genetic counselors about their chance of carrying mutations that increase disease risk. To aid them, genetic counselors use Mendelian models that predict whether the person carries deleterious mutations based on their reported family...

Genetic screening for BRCA1 and BRCA2 gives women the opportunity for early detection, surveillance, and intervention. One key feature of genetic testing and counseling is the provision of personal lifetime risk. However, little attention has been paid to how women interpret lifetime risk...