Interviews were conducted to establish a baseline for how orphan drug forecasting is currently undertaken by financial market and industry analysts with the intention of understanding the variables typically accounted for in such a model. A literature search formed the basis of subsequent...

This thesis investigates the economic impact of stratified medicine on industry and the subsequent ethical implications for patients. Stratified medicine involves the use of clinical biomarkers to indicate differential response among patients in efficacy or potential side effects of therapeutic...

The goal of this study is to explore the economic conditions that favor the joint development of therapeutics and companion diagnostics. I hypothesize that predictive biomarkers can generate economic value in drug development by increasing success rates. I construct an economic model of the...

The pipeline productivity challenge facing large, publicly traded pharmaceutical companies, collectively referred to as "Big Pharma," is well known. The unprecedented success Big Pharma achieved over the past few decades in commercializing blockbuster products means that it is now faced with...

The aim of this article is to share with readers from French, German and Spanish speaking countries, as well as other intellectuals from such countries as Italy and Brazil, the importance of universities in English-speaking countries (the United Kingdom, Australia, Canada and the United States)...

This article examines the institutionalization of public finance as a subfield of economics in American universities from the founding of professional academic economics departments in the 1880s through the eve of the Great Depression. It is argued that what became identified as the accepted...

Academic seminars are a rather recent invention. Among the seminars that flourished at Harvard during the late 1920s and early 1930s, one played a major role in creating what Margaret Gilbert (1989, 2000) calls a “joint commitment” of its members. Organized by Lawrence J. Henderson, it was...

Martin Stuart (“Marty”) Feldstein, currently George F. Baker Professor of Economics at Harvard University and President Emeritus of the National Bureau of Economic Research, Inc. (NBER), is a renowned American economist who has made important contributions to public finance, macroeconomics,...