This work is motivated by dose-finding studies, where the number of events per subject within a specified study period form the primary outcome. The aim of the considered studies is to identify the target dose for which the new drug can be shown to be as effective as a competitor medication....

This thesis discusses issues arising in the analysis of repeated measurement studies with missing data. The first part of the thesis is motivated by a study where continuous and bounded longitudinal data form the outcome of interest. The aim of this study is to investigate the change over time...

In longitudinal and multivariate settings incomplete data, due to missed visits, dropouts or non-return of questionnaires are quite common. A longitudinal trial in which potentially informative missingness occurs is the Collaborative Ankle Support Trial (CAST). The aim of this study is to...