The COVID-19 pandemic has severely tested humanity, revealing the need to develop and improve the medical, economic, managerial, and IT components of vaccine management systems. The vaccine lifecycle includes vaccine research and development, production, distribution, and vaccination of the...

Previous research has documented lower vaccination rates among ethnic and racial minorities as well as foreign-born people, thus raising concerns about health inequities during pandemics. We analyzed influenza vaccination rates among children with US-born parents and those with at least one...

The emergence of Covid-19 has affected all aspects of human life across the globe. Lockdowns everywhere are having dramatic social and economic consequences. No therapy has yet been approved, and vaccines are a priority potential tool to control the pandemic and its impacts. Multiple vaccines...

In this study, we investigate whether COVID-19 deaths that occurred before vaccination rollouts impact subsequent vaccination take-up. We use data on local vaccination rates and COVID-19-related deaths from England measured at high geographic granularity. We nd that vaccination take-up as of...

Background: Concerns about rising health care costs require rigorous economic study to inform clinical and policy decision-making. Micro-costing is a cost estimation methodology employing detailed resource utilization and unit cost data to generate precise estimates of economic costs....

Background: Faecal microbiota transplantation (FMT) is increasingly being used in the treatment of recurrent Clostridioides difficile infection (rCDI). Health economic evaluations may support decision-making regarding the implementation of FMT in clinical practice. Previous reviews have...

Aim: The productivity of pharmaceutical research and development (R&D) investments is declining due to high failure rates in clinical research. Recently, the US Food and Drug Administration (FDA) acknowledged that adaptive designs can make drug development more efficient and less costly. Our...

Voluminous vaccine campaigns are used globally since the COVID-19 pandemic owes devastating mortality and destructively unprecedented consequences on different aspects of economies. Notwithstanding different approaches to measure the effectiveness of COVID-19 vaccines in clinical medicines, this...

Hepatitis B (HBV) is one of the most common infectious diseases, with a worldwide annual incidence of over 250 million people. About one-third of the cases are in China. While China made significant efforts to implement a nationwide HBV vaccination program for newborns, a significant number of...

We study cartels that operated in the US generic drug industry, leveraging quarterly Medicaid data from 2011-2018 and a difference-in-differences approach comparing the evolution of prices of allegedly collusive drugs with a group of competitive control drugs. Our analysis highlights (i) the...

A game-theoretic setting is used to illuminate the conflict between vaccination proponents and vaccination opponents. A central result is that vaccination proponents could in principle persuade vaccination opponents to vaccinate by means of subsidization. Such a subsidy could increase benefits...

Since vaccination is the decisive factor for controlling the COVID-19 pandemic, it is important to understand the process to vaccination success. We identify a variety of factors playing a crucial role including the availability of vaccines, pandemic pressures, economic strength (GDP),...

Are IPRs institutions meant to foster innovative activities or conversely to secure appropriation and profitability? Taking stock of a long-term empirical evidence on the pharmaceutical sector in the US, we can hardly support IPRs intended as an innovation rewarding institution. According to our...

Background: Antibiotics have been overprescribed to treat infectious diseases and have generated antimicrobial resistances that reduce their effectiveness. Following the rationale behind the new paradigm of personalized medicine, point-of-care diagnostic testing (POCT) has been proposed to...

The current strategy to end the COVID-19 pandemic is to achieve herd immunity through mass vaccination. This relies on individuals’ willingness to take a vaccine. Yet little is known about how people perceive the risks and benefits of the COVID-19 vaccine. This paper reports the results of a...

Over the first half of March 2021, the majority of European governments suspended Astrazeneca's Vaxzevria vaccine as a precaution following media reports of rare blood clots. We analyse the impact of the European Medicines Agency's (EMA) March 18th statement assuring the public of the safety of...

Over the first half of March 2021, the majority of European governments suspended Astrazeneca's Vaxzevria vaccine as a precaution following media reports of rare blood clots. We analyse the impact of the European Medicines Agency's (EMA) March 18th statement assuring the public of the safety of...

The COVID-19 pandemic and the ongoing vaccination process calls for decisive, internationally coordinated and forward-looking action. We propose short-, medium- and long-term actions and emphasise that the political pressure for action should not only focus on short-term management, but on...

Ohio announced a Vax-a-Million Lottery in May 2021 to encourage people vaccinated. If people may avoid vaccination because (1) they worry about rare but critical side effects or (2) they want to free ride on herd immunity, the vaccination lottery may work better or worse than a lump-sum transfer...

Hoffnungsträger zur Überwindung der Corona-Pandemie sind die potentiellen Impfstoffe. Um die Pandemie zu beenden, wäre ein weltweiter Einsatz dieser Impfstoffe nötig. Der knappe Impfstoff steht aber nur den reichsten Ländern der Welt zur Verfügung. Bei Innovationen wie den...

The role of the patent system in the pharmaceutical sector is highly debated also due to its strong public health implications. In this paper we develop an evolutionary, agent-based model of the pharmaceutical industry to explore the impact of different configurations of the patent system upon...