This study's third phase evaluates the regulatory impact analysis (RIA) of policy recommendations aimed at enhancing the Philippine Retirement Authority's (PRA) retirement program, focusing on competitiveness and sustainability. Utilizing methodologies such as benefit-cost analysis, breakeven...

This research provides a comprehensive comparison of the financial, educational, and socio-spatial considerations in establishing State Universities and Colleges (SUCs) satellite campuses versus enhancing support mechanisms for existing SUCs in the Philippines. It highlights their critical role...

The crises of both the climate and the biosphere are manifestations of the imbalance between human extractive, and polluting activities and the Earth's regenerative capacity. Planetary boundaries define limits for biophysical systems and processes that regulate the stability and life support...

Habitat fragmentation threatens biodiversity by disrupting ecological connectivity. To support conservation planning, we evaluate which spatial connectivity metrics best predict species occurrence. We do so by comparing six common connectivity metrics as predictors of occurrence patterns of...

Agriculture is a significant source of global greenhouse gas (GHG) emissions, making reduction targets crucially needed. Worldwide, countries have set agricultural GHG reduction goals and discussed methods to reach them. A crucial aspect is, whether the policy target level is set at the...

We study Germany's photovoltaic (PV) subsidy program, estimating a dynamic model of new technology adoption which accounts for heterogeneity in residential ownership structures. We find that homeowner and landlord investors heavily discount future benefits, highlighting the suboptimality of the...

Background: Digital health interventions (DHI) have been identified as a tool that has the potential to meet the growing demand for healthcare, improve the efficiency and sustainability of healthcare, and increase the accessibility and quality of care. The adoption and use of DHI for healthcare...

This annex provides the full results of the Cost-Effectiveness Analysis (CEA) undertaken as part of the study supporting the evaluation of the European Labour Authority (ELA). It mainly helps to answer the evaluation question: To what extent were the actions of the European Labour Authority...

Background Evidence on the cost effectiveness of deprescribing in multimorbidity is limited. Objective To investigate the cost effectiveness of a general practitioner (GP) delivered, individualised medication review to reduce polypharmacy and potentially inappropriate prescribing in older...

Background The ORIENT-15 double-blind randomized controlled trial demonstrated that the addition of sintilimab to chemotherapy for locally advanced or metastatic oesophageal squamous cell carcinoma (OSCC) resulted in better clinical outcomes. In this analysis, we sought to evaluate the...

Background In their interesting systematic review, Gallehzan et al. quoted our article Cost-utility analysis of teriflunomide in naïve vs. previously treated patients with relapsing-remitting multiple sclerosis (RRMS) in Italy. While we are grateful to Gallehzan et al. for their interest in the...

Background As the number of randomized clinical trials (RCTs) demonstrating the survival benefits of combination therapies in previously treated multiple myeloma (MM) patients increases, it is essential to determine the most cost- effective treatment through robust economic evaluation. This...

Background Obesity has become major public health problem around the world. Lifestyle interventions, Pharmacotherapy and bariatric surgery are the common intervention to reduce weight in clinical practice. This study aims to conduct an economic evaluation of Duodenal-Jejunal Bypass Sleeve (DJBS)...

Objectives To conduct pooled estimates and comparative evaluations of safety and efficacy, alongside cost-effectiveness and value-based pricing analyses, for systemic treatments recommended by the National Comprehensive Cancer Network in refractory colorectal cancer. Methods A comprehensive...

Background Within Finland's breast cancer screening program, all women aged 50-69 are invited to biennial screening. Current European guidelines recommend screening in ages 45-49 and 70-74 conditional upon, inter alia, demonstrated context-specific cost-effectiveness. This study aims to...

ABSTRACT This instructional case explores strategic decision‐making at CarCompany (CarCo), a large automaker that is transitioning to battery electric vehicles. CarCo aims to reduce the carbon dioxide (CO2) emissions at their own sites and at suppliers' sites. The challenge is to select a...

Background In patients with asthma uncontrolled by a medium or high-strength (MS/HS) inhaled corticosteroid (ICS) plus long-acting β2-agonist (LABA), according to Global Initiative for Asthma (GINA) guidelines, a maintenance therapy option is the addition of a long-acting muscarinic antagonist...

Background The purpose of this study was to compare the length of stay (LOS) and costs of diagnostic workup by Ultra Low Dose (ULD) chest computed tomography and radiography for patients treated for a community-acquired pneumonia (CAP) in the emergency department (ED). Methods We conducted a...

In 2015, the 21st Conference of the Parties reaffirmed the target of keeping the global mean temperature rise below 2 °C or 1.5 °C by 2100 while finding no consensus on how to decarbonize the global economy. In this regard, the speed of decarbonization reflects the (in)flexibility of...

This study's third phase evaluates the regulatory impact analysis (RIA) of policy recommendations aimed at enhancing the Philippine Retirement Authority's (PRA) retirement program, focusing on competitiveness and sustainability. Utilizing methodologies such as benefit-cost analysis, breakeven...

This research provides a comprehensive comparison of the financial, educational, and socio-spatial considerations in establishing State Universities and Colleges (SUCs) satellite campuses versus enhancing support mechanisms for existing SUCs in the Philippines. It highlights their critical role...

This cost-effectiveness analysis (CEA) was undertaken as part of the Study supporting the evaluation of EU Agencies: Eurofound, Cedefop, ETF and EU-OSHA. It provides supplementary detail to the summary analysis provided within the main evaluation report to RQ 8: To what extent were the...

Objective This study compared the clinical efficacy and cost-effectiveness of parenteral iron, using intravenous iron sucrose (IVIS) therapy against the standard regimen of oral iron (OI) therapy for managing iron-deficiency anemia (IDA) among pregnant women in a natural primary care setting in...

Background Clinical trials have demonstrated the efficacy of edaravone dexborneol in the treatment of acute ischemic stroke. This study aims to determine the cost-effectiveness of edaravone dexborneol compared with human urinary kallidinogenase from China's healthcare system perspective. Methods...

Background Multiple sclerosis (MS) is a chronic, autoimmune, and inflammatory disease. The economic burden of MS is substantial, and the high cost of Disease-modifying drugs (DMDs) prices are the main drivers of healthcare expenditures. We conducted a systematic review of studies evaluating the...

Background To estimate the long-term cost-effectiveness of once-weekly semaglutide versus sitagliptin as an add-on therapy for type 2 diabetes patients inadequately controlled on metformin in China, to better inform healthcare decision making. Methods The Cardiff diabetes model which is a Monte...

There are no standards in diagnostic and therapeutic approaches to eye care in incomplete eyelid closure due to unresolved facial palsy (FP). Loading of the upper eyelid (UELL) with gold weights (GWs) or platinum chains (PCs) is a highly effective procedure for the correction of lagophthalmos....