Marijuana prohibition ended in Canada in 2018 when marijuana was legalized at the federal level. Marijuana prohibition in the United States has de factor ended in a large percentage of states as marijuana has been legalized at the state level (even while it remains illegal under federal law)....

In order to investigate the difference of aromatic substances among flavored cigarette paper, which supplied by several manufacturers with different batches, the stability of the complex system of scented cigarette paper was analyzed and evaluated. In this study, H eadspace-gas...

Metabolic conversion of drugs to chemically reactive products, known as bioactivation, is considered to underlie the adverse drug reactions such as idiosyncratic hepatotoxicity. As bioactivation of most drugs involves phase I oxidation, UV-induced TiO 2 photocatalytic oxidation (UV/TiO 2 -PCO)...

Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances (RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended towards comparative in-silico predictions for drugs and RS. This may lead to the assessment of drug likeliness of nontoxic RS as...

Cutaneous infections involving pathogenic biofilms cannot be effectively treated by topical therapies, partially due to the resistance and the poor penetration of therapeutics. To overcome these limitations, we propose a multi-functional microneedle device that can penetrate through the stratum...

The benefits of multi-target drugs in oncotherapy are often hindered by their multi-target nature and tissue-nonspecific distribution. To maximize the multi-target antitumor potency with reduced side effects, we proposed a ROS/pH-dual responsive nanosystem (DP) constructed from biocompatible...

Fatal car crashes are a leading cause of death among younger Americans and have become a central concern in the US marijuana policy debate. I provide new evidence on the effect of marijuana on traffic fatalities by exploiting zip code level data on the opening of recreational marijuana...

In the current legal landscape, it is possible to craft policy that combats drug abuse and drug harms, protects human rights, and complies with international drug control law in good faith, by regulating the recreational uses of cannabis products rather than outlawing them. This essay proposes...

As part of a Nixon-era set of reforms, the Controlled Substances Act (CSA) was not intended to be a harsh, punitive approach but in the intervening years, the CSA lost its original purpose as political winds changed in ways that focused more on punitive approaches to drug control. Moreover, the...

The COVID-19 pandemic caused increased drug use and a widespread decline in mental health throughout American society. Yet, despite the unprecedented pandemic, society as a whole has shown an impressive ability to adapt to new ways of living, suggesting that a dramatically different version of...

The demand for high-performance energy storage devices such as supercapacitors and lithium-ion batteries has been increasing to meet the application requirements of renewable energy systems. Here, high energy and power density Ti doped WO 3 supercapacitor is reported based on the modified glassy...

We examine the impact of the drug crisis that has unfolded over the last three decades in the United States on children’s living arrangements and environments. Because the current living arrangement could be a result of events that occurred at any point in a child’s life, we measure...

The labor-force participation rates of prime-age U.S. workers dropped in March 2020—the start of the COVID-19 pandemic—and have still not fully recovered. At the same time, substance-abuse deaths were elevated during the pandemic relative to trend indicating an increase in the number of...

We investigate the effect of teenage driving on mortality and risky behaviors in the United States using a regression discontinuity design. We estimate that motor vehicle fatalities rise by 40% at the minimum legal driving age cutoff, implying a mortality risk per additional mile driven 6-9...

Using information from the all-payer claims database for Rhode Island covering more than three-quarters of health insurance enrollees in the state from April 2011 through May 2019, this paper offers new measures of the association between the Medicaid expansion and the rate of receipt of...

We investigate the relationship between opioid diverting policy and suicides among the U.S. veteran population. The opioid epidemic of the past two decades has had devastating health consequences among U.S. veterans and military personnel. In 2013, the Veterans Health Administration (VA)...

The opioid epidemic continues to wreak havoc across the United States. To abate the crisis, state policymakers have enacted both supply-side (i.e., restrictions on physicians and pharmacies) and demand-side (i.e., managing customer demand) regulations to curb the pernicious effect of unfettered...

Marginal prices fell, and disposable incomes increased, for drug and alcohol consumers during the pandemic. Most of the amount, timing, and composition of the 240,000 deaths involving alcohol and drugs since early 2020 can be explained by income effects and category-specific price changes. For...

Alcohol and other drug use disorders are among the most difficult problems facing many employers and society at large. Business firms and other organizations can establish policies that help workers avoid and overcome substance use disorder. This article describes the extensive negative...

Conditional on a set population of opioid-dependents, opioid fatalities are a function of the total quantity available and the ease of accessing that quantity. While other studies examine policy changes affecting aggregate supply, I focus on the effects of easing access by changing the trade...

U.S. states have taken varied approaches to licensing cannabis businesses under federal prohibition, but up to now there is limited research on cross-state licensing approaches. This paper provides a systematic analysis of the current licensing strategies taken by all states that have passed...

Greek-letter student social groups, better known as fraternities and sororities, are a ubiquitous feature on many American higher education campuses. These organizations, especially fraternities, have a reputation for encouraging unruly and improper behavior among both members and non-members....

The COVID-19 pandemic has highlighted problems regarding scarcity of lifesaving medicines. During pandemics and epidemics, a sudden surge in demand for medicines is often unmatched on the supply side. Moreover, the same intellectual property rights that are supposed to incentivize their creation...

Ayurveda medicine system has a strong background in Indian culture. Modernized practices derived from Ayurvedic culture is used as alternative medicine in the field of Ayurveda. In this system of medicine, there is a belief that, through Ayurveda protocols, any substance can be changed into...

A growing literature has examined how mandatory access prescription drug monitoring programs (MA PDMPs), laws that require providers to consider a patient's prescription history before prescribing controlled substances, affect opioid-related outcomes. However, little is known about their impact...

More than a dozen Federal policy changes since the year 2000 have affected incentives to prescribe, manufacture, and purchase both prescription and illicitly-manufactured opioids. To the extent that one of the policies, the 2013 “Holder memo,” had a meaningful effect on the cost structure of...

In this paper, I study the role of payday loan restrictions on suicide and overdose deaths. Payday lenders offer ``quick cash'' and charge high fees relative to the principle loan amounts. Concerns about payday loans trapping borrowers in debt have led 21 U.S. states and the District of Columbia...

Without the opioid epidemic, American life expectancy would not have declined prior to 2020. In turn, the epidemic was sparked by the development and marketing of a new generation of prescription opioids and provider behavior is still helping to drive it. There is little relationship between the...

With the change in legal status, marijuana is not really being legalized or even just decriminalized. It is being made regulatable or, to coin a phrase, regulatabilized. Markets in illegal goods — along with the goods’ creation, cultivation, distribution, taxation, sale, etc. — are...

The opioid crisis has implications for firms which must now contend with a lower supply of workers. Consistent with a labor shortage explanation, we find a negative effect of instrumented opioid prescriptions on subsequent individual employment. Similarly, we show a negative relationship between...

Using data on banking transactions, we analyze how people changed their spending behaviour when recreational cannabis became legal in Canada. In the data set, we identify people with purchases in a cannabis store after the legalization. We apply a difference-in-difference approach to compare...

We investigate the economic consequences of access to banking institutions. To do so, we examine the legal marijuana industry, where only half of businesses have access to cash management services from a financial institution. We quantify the benefits of cash management in terms of differences...

I discuss economic approaches to the demand for harmfully addictive substances and estimate time-series demand functions for the period from 1975 through 2003. My estimates suggest that changes in price can explain a good deal of the observed changes in cigarette smoking, binge alcohol drinking,...

A comprehensive toolkit –for decision-makers, researchers, advocates, and stakeholders– to understand why an appropriate policy address to cannabis is critical if we are to achieve sustainable, resilient, fair, and modern societies. Updated and extended version of the previous progress...

This study examines the effects of local cocaine and heroin prices, AIDS rates, and needle exchange programs on drug injection and needle sharing by adult male arrestees in 24 large U.S. cities during 1989 1995. Regressions that control for personal characteristics including income, fixed city...

Marijuana legalization creates a host of complex legal problems, not the least of which is how to best tax the emerging legal market. This Essay attempts to bridge the gap between tax theory and marijuana policy to make some modest claims. First, it roots the discussion of state-level marijuana...

Polydrug abuse is common among substance abusers, but few empirical or theoretical methods accurately characterize this phenomenon. This chapter describes a simulation paradigm that was developed to apply a behavioral economic analysis to understanding polydrug abuse. Heroin abusers 'purchased'...

This study uses data from the Children of the National Longitudinal Survey of Youth to test for evidence of a causal relationship between maternal alcohol use, marijuana use and cocaine use, and children's behavior problems. Ordinary least squares results provide strong evidence that maternal...

College campuses have been cracking down on underage and binge drinking in light of recent highly publicized student deaths. Although there is evidence showing that stricter college alcohol policies have been effective at discouraging both drinking in general and frequent binge drinking on...

This paper estimates the impact of opioid abuse on real estate prices. We exploit the variation in opioid prescriptions induced by the staggered passage of state laws intending to limit the abuse of opioids. We document a long-term negative relationship between opioid prescriptions and...

Drug use and welfare are two serious social problems that have received widespread public attention. Recently, it has been suggested that illicit drug use is a major cause of welfare, although there is only anecdotal evidence to support such a claim. This paper provides the first systematic...

An emerging literature considers the role of the opioid crisis on labor outcomes, suggesting that increased access to opioids may have led to decreased national labor supply. This paper uses the introduction of OxyContin and geographic variation in its launch to study the labor supply...

This paper examines the effects of cocaine and marijuana use on the wages of a sample of young adults drawn from the NLS Youth Cohort. The endogeneity of drug use in a wage equation is considered and a 2SLS procedure is implemented. The rather surprising results suggest that for this sample,...

This paper estimates the empirical relationship between the prices of cocaine and heroin and objective indicators of use. The set of outcomes is drug related hospital emergency department admissions where cocaine and heroin are cited, for 21 large U.S. metropolitan areas. These outcomes are...