The impact of the COVID-19 pandemic appears to be quite uncertain across the globe. Due to the COVID-19 pandemic, all countries in the world face severe and big health and economic issues. The nations are trying to overcome its impact on their economies. The pandemic has affected production, distribution, and lifestyle. The coronavirus pandemic has taken more than over 6 million lives globally and paralyzed the global economy. The impact of a pandemic is global in nature, however, challenges for developing countries are more serious to combat its adverse impacts due to the limited recourse they have to tackle such uncertainties.If we look at the South Asian region's health infrastructure scenario to tackle the COVID-19 pandemic, Afghanistan has 2800 physicians for one million people, Bangladesh 5300, Bhutan 3800, and Nepal 6500, one-tenth as compared to advanced countries. Even India, which has a health care system more advanced as compared to neighborhoods, has 7800 physicians per one million people. This condition seems to be worse in Pakistan, which has 980 physicians per one million people and most of the local hospitals have no functional health care system and administrative infrastructure. (Saraceno et al., 2007; World Health Organization, 2020).Pakistan also faces a substantial economic setback from the outcome of the coronavirus situation. To curb the spread of the coronavirus pandemic, the Government of Pakistan has taken different initiatives like complete and smart lockdown to control the pandemic as much as possible. In this context, the study examines the impact of the demand-side and supply-side shocks due to the COVID-19 pandemic on the Pakistan economy. On the supply side, this pandemic has halted the domestic and international supply chain, causing a shortage of inputs and necessities. On the demand side, decreased domestic and international demand has resulted in massive layoffs and poverty scares. The study also analyzes the Pre & Post COVID-19 pandemic economy of Pakistan. The study also discusses in detail the adverse impact of coronavirus on the major sectors of the economyThese unprecedented circumstances call for policy changes in order to save millions of people from economic and health crises. Therefore, setting up priorities especially when countries have poor hygienic, health, social, and economic infrastructure, strategic thinking, and planning play a significant role in low-income countries to control COVID-19 challenges.The primary challenge facing the policymakers of underdeveloped countries is how to utilize limited resources to achieve interconnected goals (Turnpenny et al., 2008; UN-Habitat, 2016) for managing health and economic recovery from, crises, and creating environmental sustainability. The interconnected nature of COVID-19 crises demands an integrated approach and coordination between all stakeholders to handle the pandemic in a significant way. Therefore, the study tries to Identify the best set of policies and guidelines to handle COVID-19 Pandemic challenges and align them for a sustainable recovery from the pandemic.This policy paper will also deal with challenges and policy prioritizing actions for quick and sustainable recovery from uncertainties like pandemics. The outline of this article facilitates the policy makers for accessing the prioritizing policy options for planning and decision building