A multinomial model for the quality control of colony counting procedures

by B. Voss, S. Dahms, J. Kunert and H. Weiss

The so-called good-laboratory-practice (GLP) test provides an experimental design and appropriate statistical analysis for the problem of analyst performance assessment in microbiological laboratories. For a given sample material multiple dilution series are generated yielding colony counts from several dilution levels. Statistical evaluation is based on the assumption of Poisson-distributed colony forming units. In this paper a new model based on conditional binomial and multinomial distributions is presented and it is shown how it is related to the standard model which assumes Poisson-distributed colony counts. The effects of common working errors on the statistical evaluation of the GLP-test are investigated.

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Year of publication:	1999
Authors:	Voss, B. ; Dahms, S. ; Kunert, Joachim ; Weiss, H.
Publisher:	Dortmund : SFB 475, Universität Dortmund
Subject:	standardized analytical methods \| Good-laboratory-practice-test \| Poisson model \| multinomial model \| quality control \| Qualitätsmanagement \| Quality management \| Theorie \| Theory