Acute Toxicity of Four Organophosphorus Pesticides Products
Acute toxicity of phoxim, acephate, isofenphos-methyl and isocarbophos on male SD rats of clean grade was carried out by gastric lavage method at room temperature of 18℃. These rats are 4 to 5 months old with body weight of 180 to 220 kg. The results indicate that the orders of the toxicity of these four pesticides on SD rats are isofenphos-methyl, isocarbophos, acephate, phoxim. We found that the median lethal concentration of phoxim in 24 h, 48 h, 72 h and 96 h is 3.892g/kg, 3.051 g/kg, 2.618 g/kg and 2.458g/kg respectively; the median lethal concentration of isofenphos-methyl in 24 h, 48 h, 72 h and 96 h is 0.015g/kg, 0.013g/kg, 0.012g/kg and 0.011 g/kg respectively; the median lethal concentration of isocarbophos in 24 h, 48 h, 72 h and 96 h is 0.049 g/kg, 0.046 g/kg, 0.043 g/kg, 0.041 g/kg respectively; and the median lethal concentration of acephate in 24 h, 48 h, 72 h and 96 h is 0.137 g/kg,0.113 g/kg, 0.100 g/kg,0.085 g/kg respectively. Finally, we evaluated the characteristics of toxicity effect and safe concentration of these pesticides to SD rats.
Year of publication: |
2012
|
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Authors: | Li, Peng ; Yin, Ya-ling ; Wang, Qian-qian ; Zhao, Fan-rong ; Pan, Guo-pin ; Zhang, Yu-lin |
Published in: |
Asian Agricultural Research. - USA-China Science and Culture Media Corporation. - Vol. 04.2012, 05
|
Publisher: |
USA-China Science and Culture Media Corporation |
Subject: | Phoxim | Acephate | Isofenphos-methyl | Isocarbophos | Acute toxicity | SD rats | Agribusiness |
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