Amplifying Catalytic Therapy by Photothermal Effect of AU Composited and Mn-Doped Single Atom Nanozyme

As an emerging technology, nanocatalytic medicine attracts much attention, especially the ones according to the enzymatic reaction by using excess H2O2 in tumor. Among various candidates, single atom catalyst (SAC) reveals unique and outstanding redox reaction performance, since the active sites consisting of single metal atoms may achieve the maximum utilization of metal atom and emerge obviously amplified reaction rate. Here we developed a Mn-Nx center based SAC with hollow structure by calcination of Mn2+-doped zeolitic imidazolate frameworks (ZIF-8), and PEGylation was applied to improve the hydrophilicity. According to enzymatic reaction, the Mn-N x centers have inherent peroxidase-like activity to catalyze over-expressed H2O2 in weak acidic tumor microenvironment and generate large amount of toxic reactive oxygen species (ROS) like hydroxyl radicals for therapy. To keep efficient therapeutic output, we integrated the hollow SAC with Au which could expend the glucose in tumor and supply H2O2 as the substrate of peroxidase-like activity. Better yet, Au may boost the photothermal effect of SAC and offer another non-invasive photothermal therapy (PTT) to promote the effect of tumor removal. This platform provided a new idea for the construction of more efficient peroxidase-like activity in tumor therapy