This chapter provides basic knowledge on the principles used in modern signalling systems to ensure safe train separation and to establish safe routes through point zones. For train control, lineside signals are compared with cab signalling. For block protection, fixed block and moving block systems are covered. The described interlocking principles for routes leading through point zones include route locking and release, conflicting routes, flank protection, and overlaps. A section on automatic train protection explains the principles of how trains can be prevented from violating speed and authority limits. For this, an overview on the levels of the European Train Control System is provided. Some information is also given on train describers and automatic route setting systems to support traffic management in signalling centres.