Human Capital and Regional Development<xref ref-type="fn" rid="qjs050-FN29"></xref>

We investigate the determinants of regional development using a newly constructed database of 1,569 subnational regions from 110 countries covering 74% of the world's surface and 97% of its GDP. We combine the cross-regional analysis of geographic, institutional, cultural, and human capital determinants of regional development with an examination of productivity in several thousand establishments located in these regions. To organize the discussion, we present a new model of regional development that introduces into a standard migration framework elements of both the <xref ref-type="bibr" rid="qjs050-B48">Lucas (1978)</xref> model of the allocation of talent between entrepreneurship and work, and the <xref ref-type="bibr" rid="qjs050-B49">Lucas (1988)</xref> model of human capital externalities. The evidence points to the paramount importance of human capital in accounting for regional differences in development, but also suggests from model estimation and calibration that entrepreneurial inputs and possibly human capital externalities help understand the data. JEL Codes: O110, R110, I250. Copyright 2012, Oxford University Press.