Mathematical modelling of endocrine and metabolic systems: Model formulation, identification and validation

An integrated modelling methodology for metabolic and endocrine systems is presented. Particular emphasis is given to model identification and validation and their inter-relationship. Both theoretical and practical identifiability analyses are reviewed. Model validation, involving multidimensional concepts of validity, is carried out both within the modelling process and upon the completed model. The validation procedures are outlined for models which are theoretically identifiable and for those which are not.