The Segmentation, Targeting, and Positioning (STP) framework remains a cornerstone of strategic marketing, enabling firms to effectively reach and influence their intended audiences. In this chapter, we revisit the classic STP model through a modern lens—accounting for the proliferation of data, AI-driven segmentation tools, and personalization technologies that have reshaped its application. Segmentation is examined not only through traditional demographic and psychographic lenses but also through behavioral, contextual, and predictive analytics. We explore advanced targeting strategies that allow firms to address micro-niches with precision and agility. Positioning is then framed as a dynamic process of crafting brand meaning in a crowded, digital-first marketplace, where perception is shaped in real time. Practical tools, visual models, and real-world brand examples are provided to guide readers in designing an effective and adaptive STP strategy across global markets.