Background: Simulation techniques are well suited to modelling diseases yet can be computationally intensive. This study explores the relationship between modelled effect size, statistical precision, and efficiency gains achieved using variance reduction and an executable programming language....

Introduction: Immunosuppressive therapy is required to prevent graft rejection. Calcineurin inhibitors such as tacrolimus are paradoxically toxic to the kidney, whereas sirolimus (rapamycin; Rapamune(R)) is not generally associated with the nephrotoxicity of CNIs. The purpose of this study was...

Upstream inflow decline and excessive water withdrawal are the major reasons for failure in maintaining ecological functions of wetlands and could lead to wetland drought and degradation. Quantitative evaluation of wetlands drought constitutes the basis for managing and scheduling water...

A total of 81 mountain tunnels that were damaged in 10 strong earthquakes are studied. They are classified into six typical damage characteristics: lining cracks, shear failure of lining, tunnel collapse caused by slope failure, portal cracking, leaking, and deformation of sidewall/invert...

Based on the daily precipitation data of 38 weather stations in the Huai River Basin from 1961 to 2010, this study used SPI index, P-III curve to determine the flood/drought years, under what situations for droughts and floods easily happen, and to analyze the evolution law of flood and drought...

The availability of entecavir in Australian clinical practice should make long-term suppression of hepatitis B virus replication increasingly attainable, resulting in fewer CHB sequelae, at an acceptable financial cost. </AbstractSection> Copyright Adis Data Information BV 2008