Highly Selective Paper-Based Chip as Biomimetic Recognition Module Integrated Lateral Flow Platform

The development of high-integration microanalytical device is a challenge for rapid detection of harmful residues in foodstuff. In this study, we propose a new lateral flow platform constructed using a paper-based boronate affinity metal–organic framework/molecularly imprinted polymer chip (FZS@CPBA@MIP) as recognition module. For this chip, a zeolitic imidazole framework was selected as the scaffold, grew via the seeded growth method on filter paper. Subsequently, the FZS@CPBA@MIP was prepared based on a highly oriented boronate affinity surface imprinting strategy. In order to validate the effectiveness of the integrated lateral flow platform, the visual and exclusive detection for kanamycin in dairy products was achieved using kanamycin as a template molecule, and the entire analysis process was accomplished within 30 min. In brief, this study offers a new lateral flow assay integrated platform for visually detecting harmful veterinary residues containing cis -diols, promising a significant advance in detecting hazardous compounds containing glycosyl in foodstuff